What are Beta Blockers?

Beta blockers are a class of drugs that are most commonly used to treat heart problems; short for Beta- adrenergic blocking agents. These drugs prevent epinephrine (adrenaline) and norepinephrine (noradrenaline) from binding to the beta cells located on your nerves resulting in slowed transmission of nerve impulses to the heart (Beta 1 receptors – there are three different beta receptors located on cells – 1, 2 and 3). Once nerve impulses are slowed, the heart requires less blood and oxygen to function, slowing heart rate and preventing blood vessel constriction. Under normal circumstances, when beta 1 cells are stimulated, heart rate increases, and your blood vessels constrict to allow more blood to flow to your skeletal muscles. This is an important adaptation in our bodies, readying them for fight or flight when faced with imminent danger; your heart beats faster, bringing a fresh supply of oxygen to your skeletal muscles, allowing you to run or fight; an evolutionary adaptation. At the same time, blood flow is redirected away from your digestive system as your body needs to worry about the immediate danger in front of it, not with everyday functioning; where you have trouble figuring out priorities, your body decides for you!

The problem with this system, and thus one of the reasons why Beta blockers are prescribed, is that if your heart muscle is damaged, or if you have arrhythmias, or one of many other heart conditions, any increase in workload puts  you at risk for sustaining further heart damage. Beta blockers have negative inotropic and chronotropic effects:

What is an Inotropic Effect?

Inotropic refers to the strength at which a muscle contracts. A negative inotrope decreases the strength of a muscle contraction and a positive inotrope increases the strength of a muscle contraction. Beta blockers are negative inotropes – if your heart doesn’t beat as “hard” it is less likely to break down. Drugs like Milrinone have the opposite effect; they increase the contractility of the heart and are used in some cases of congestive heart failure.

What is a Chronotropic Effect?

Chronotropic refers to the speed at which the heart beats. Negative chronotropic agents, such as beta blockers, decrease the hearts contraction rate.

In summary beta blockers work to decrease heart rate (beats per unit time) and the strength of the heart contraction protecting it from incurring further damage.

What is the History of Beer?

The Story of Beer, by guest writer Matt Williams
Did you know that beer is one of the world’s oldest beverages?  At roughly eleven thousand years of age, it is almost as old as agriculture and civilization itself!  This should not come as a surprise, seeing as how the prerequisites for making beer – the cultivation of grains, clay containers, and cool storage places for it to sit and ferment – all are markers of early civilization.  Since that time, it has grown to become one of the most popular “adult” beverages in the world.  It’s total global consumption is four times that of wine, and even in societies where alcohol is forbidden (places like Lebanon, Iraq, Syria, and many Islamic African nations), it is considered an indispensable part of social interaction.  Like it or not, beer is a part of our social and cultural makeup and doesn’t appear to be going anywhere.

But how and why beer came to be is still the subject of debate.  The first recorded indications of beer are from ancient Mesopotamia, dated from ca. 4000 BC, where clay tablets with cuneiform writing informed scholars of the importance of beer to the people’s daily lives.  It was considered equal only to bread making, and was done primarily by women.  The best that historians can gauge, at some point in Sumerian history, someone must have accidentally dropped a loaf of bread into a clay urn and forgotten about it.  The bread then fermented to form Wort, the mash that is created when natural sugars in grain are allowed to combine with yeast to produce alcohol.  When they returned, the mixture must have then been sampled, with deleterious effects!  From then on, beer was in indispensable part of Sumerian society.  In fact, other cuneiform records indicate that beer was rationed in Sumerian (and later, Babylonian) society.  Peasants were entitled to three liters a day, the aristocracy was entitled to four, and priests rang in at the top of the hierarchy, drinking a whopping five liters a day.  (On a possibly related note, did you know that the average life expectancy was in the mid-twenties?)

Much like agriculture, beer making then spread throughout the Fertile Crescent, to North Africa, and then Europe.  Egyptians are known to have produced both, possibly indigenously. Like the ancient Mesopotamians, they combined baked bread with water to produce the alcoholic Wort.  And like their predecessors, they considered it to be the nectar of the Gods.  Priests drank the lion’s share of it, mainly to assist in their spiritual practices.  The Greeks and Romans drank it heavily, and continued to do so even after the invention of wine.  Wine became the drink of choice of the aristocracy, but beer remained popular amongst the plebeians, and was seen as the choice of the “barbarian hordes”.   By this, of course, they meant Europeans.  Many Roman sources claim that the German tribes were especially fond of beer, which they fashioned from wheat and fruit.

Aside from the mention from Roman sources, oral traditions tell us much about beer making in Europe.  Modern archaeology now places the introduction and spread of beer through Europe at about 3000 BC.  This was carried out largely by Celtic tribes, who were themselves renowned agriculturalists.  Beer was brewed mainly on a domestic scale, and alongside the basic starch source, the early European beers contained fruits, honey, numerous types of plants, spices and other substances such and “special” herbs.  As already mentioned, wheat was also a favorite among the later Germanic peoples when making their brew.  “Whitbear” and “HeffeWeizen” (Wheat beer) remain staples of the German brewing industry to this day.

With the fall of the Roman Empire, beer once again became a favorite amongst social drinkers and alcoholics alike during the Middle Ages.  Often, creative brewing processes led to bad batches of beer that caused people to hallucinate, get sick and even die.  This was attributed to “beer witches”, who were then burned at the stake.  It was not until sometime later that brewers began to understand that perhaps it was their choice of ingredients.  As a result, mushrooms and herbs (like wormwood) were no longer added.  Instead, brewers began to rely increasingly on a flowery plant known as hops.  These, when combined with wort, were known to give beer a crisp, bitter taste, and even helped it to keep longer.  The first recorded mention of hops in Europe was around 822, by a Carolingian Abbot and again in 1067 by the great historian Abbess Hildegard of Bingen.  The Trappist Monasteries of Belgium began using it exclusively by the 15th century, and in 1516, the Bavarian Purity Law was passed stipulating that beer be made using only water, hops, barley (or wheat), and yeast.  This tradition remains in effect to this day, though many breweries are returning to their “noble” roots by adding fruit and other flavorings to their product.

Several other developments took place during this time.  Traditional beer was known as “Ale”.  Ale relied on top fermenting yeasts, a fermentation process that took place at warmer temperatures, and was not strictly controlled.  This resulted in a beer that was fruitier, maltier, and more complex to the palate.  Several types of beer, which we are still familiar with today, emerged all over Europe.  The best known amongst these are “Pale Ale”, “Auburn Ale”, “Stout”, andPorter”, which are still served in large quantities to this day.  In addition, by the late Middle Ages, a new type of beer was being made.  This beer was fermented at lower temperatures, resulting in bottom fermenting yeast, and the result was a crisper beer, best when served cold, and generally more refreshing.  This new form of beer was known as “Lager”.  Several types of it emerged since the Middle Ages, which included “Marzen”, “Bock”, and “Pilsner”.  These all gained widespread popularity all over continental Europe while the British Isles remained havens for more traditional Ales.  For beer drinkers, the debate still rages over which is better, lager or ale.  (It should also be noted that at this time, beer became more and more the task of men.  Whether this was due to the myth of “beer witches” or the realization that beer was big business, men gradually supplanted women as the brew masters.  For shame!)

Another major development in the history of beer occurred shortly thereafter: the Industrial Revolution.  Beer produced before this time continued to be made and sold on a domestic scale.  With the introduction of steam engines and automation, however, the production of beer moved from artisanal manufacture to industrial manufacture, and domestic manufacture ceased to be significant by the end of the 19th century.  The development of hydrometers and thermometers changed brewing by allowing the brewer more control of the process and greater knowledge of the results.  Louis Pasteur’s research was another boon, in that the newfound knowledge of bacteria allowed for the development of yeast cultures, filtration, and pasteurization.  All of this meant that beer could not only be made on a large scale, it could also be counted on to keep longer, which allowed for large scale export.  By the end the 19th century, beer became a business without borders, with major breweries exporting from all over the world.

Today, the brewing industry is a global business, consisting of several dominant multinational companies and many thousands of smaller producers ranging from brewpubs to regional breweries. As of 2006, more than 133 billion liters (35 billion gallons), the equivalent of a cube 510 meters on a side, of beer are sold per year, producing total global revenues of $294.5 billion (£147.7 billion).  It remains an industry run for, and targeted overwhelmingly to, men, but women are becoming increasingly involved in both the production and consumption aspects once again.  Craft brewing is also becoming fashionable again, as the growth of brewpubs and microbreweries clearly indicates.  Who knows what the future holds?  How will future technological or social developments affect our attitudes towards beer?  One thing remains clear though: beer is and probably always will be an indispensable part of our culture.

Sources:

http://en.wikipedia.org/wiki/Beer

http://www.alabev.com/history.htm

http://en.wikipedia.org/wiki/Lager

http://www.alabev.com/history.htm

http://www.beerhistory.com/library/holdings/raley_timetable.shtml

http://inventors.about.com/od/bstartinventions/a/beer.htm

http://www.fosters.com.au/enjoy/beer/history_of_beer.htm

http://en.wikipedia.org/wiki/Wort

http://www.thebeerguy.ca/

What Are Shin Splints?

Shin splints is the general term given to pain experienced in the shin area of the leg and is not a specific diagnosis, but rather a convenient term to describe a number of possible physical processes at work; most commonly associated with the tibia. The tibia and fibula are the two leg bones between the knee and foot; the fibula is on the outside of the leg and much thinner than the tibia which sits on the inside of the leg. Pain in this area is most commonly caused by stress to the muscles, tendons or ligaments connected to the tibia. This stress can be caused by an increase in intensity or duration of exercise, or in athletes who endure a lot of shock to the legs; for example, marathon runners. Pain associated with this condition is called medial tibial stress syndrome, the attachment point on the tibia for the soleus and tibialis posterior muscles. This is half way between the knee and the foot on the inner surface of the tibia. In addition to marathon running, and dramatic exercise increases, the shape and locomotion of your foot can cause this syndrome. If you overpronate; your foot flattens out too much when standing upright, your foot will roll inwards placing stress on the muscles and tendons attaching to the tibia.

Another cause of shin splints is a stress fracture in the tibia.  Unlike acute fractures that happen with impact stress and are instantaneous – breaking a leg skiing or falling; or breaking a bone in a car accident – large, instant traumas, stress fractures are usually caused by low forces acting on a bone over a long period of time. Also known as fatigue fractures, these breaks occur in athletes who do a lot of running and jumping on hard surfaces; dancers and runners.

Undiagnosed shin pain can be caused by Compartment syndrome. If you look at a cross section of the muscles and bones below the knee, you will see different pockets with the various muscles that make up the lower leg – these pockets, or compartments can contain one or several different muscles wrapped in fascia. Think of fascia like connective tissue shrink wrap surrounding your muscles. If, in the course of training, one of these muscles becomes too big for its compartment, it will cause stress and pain in the surrounding tissue. This is one cause of compartment syndrome. Another cause is swelling or bleeding resulting from a traumatic event.

Permanent treatment usually involves surgery – splitting the fascia; followed by careful rehabilitation. Short term treatments involve rest, physiotherapy and possibly orthotics.

My standard disclaimer – I am not a doctor, nor should any of the above information be taken as medical advice. I provide the above for informational interest. If your reaction to the above is “huh”, or “interesting”, my job is done.

What Are Shingles?

Shingles is caused by the Varicella zoster virus, the same virus that causes chicken pox. A typical case of shingles starts out as chicken pox as a child. You will contract the virus, break out in the spots, and hopefully in two weeks, be symptom free, but the VZV can lie dormant in your nervous system and 10-20% of people who have had Chicken Pox will go on to develop shingles.

What are the symptoms of shingles?

In the prodromal stage, between 2 and 5 days before a rash breaks out, you feel like you are getting the flu – fever, chills, nausea. You may also feel numbness, tingling, itching or pain on one side of your body or face. The VZV lies dormant in your nerve cells. The symptoms you feel on your body follow nerve pathways.

Small, clear fluid filled blisters appear in the eruptive stage. These blisters resemble chicken pox and follow the same nerve pathways where you may have already experienced itching, numbness, tingling and/or pain. These blisters can range from somewhat irritating to incredibly painful. They tend to appear in bands or clusters called dermatomes; an area on the skin where a single nerve cell provides sensation. Dermatomes are sort of like a road map of which nerves supply which areas of the body with sensation. In about 2 weeks, the blisters will become pus filled – your white blood cells hard at work – eventually dry up to form scabs. At this point, the blisters no longer contain the active virus. The blisters and inflamed area surrounding them can be uncomfortable for 3 to 5 weeks; most symptoms are resolved within 5 weeks with no lasting scars – unless the blisters were scratched open to become infected. Most healthy people don’t experience complications from shingles. The course of the illness may even be shortened if you manage to see your doctor and are started on a course of antivirals within the first 3 days of the rash appearing.

Complications

Elderly people and those with compromised immune systems may experience complications. Postherpetic neuralgia (the VZV is in the herpes family of viruses) occurs when pain associated with the rash persists for months or years following an outbreak. Nerves can be damaged from a shingles outbreak. Damaged nerves can send faulty messages that they body interprets as pain. Nerve damage is incredibly difficult to heal. Patients over the age of 50 seem to be most at risk for developing PHN.

Hutchinson’s Sign in a shingles outbreak is a rash appearing on the tip of your nose. This sign indicates VZV infection of the ophthalmic nerve. Temporary blindness and eye swelling and should be seen by a doctor immediately. Ramsay Hunt Syndrome occurs when the VZV invades the facial nerve. Intense pain in the ear combined with dizziness, hearing loss and blisters in and around the face, ear, neck and scalp should also be seen by a doctor right away.

Bacterial skin infections can result from scratching your skin open; creating a doorway for bacteria to get into the body. In an already weakened immune system, your body may not be able to fight off these additional pathogens.

Infections in your internal organs may occur in patients with compromised immune systems.

My little disclaimer…

I am not a doctor or medical professional. This article is meant for informational interest only and should not be used in place of a physician’s diagnosis.

What are the Different Kinds of Martial Arts?

The term “Martial Art” literally means the “Art of Warfare” and is derived from Mars, the Roman God of War.  In common usage, it refers to different systems of combat originating in East Asia, Europe and the Americas; with the main bulk originating from East Asia. The body and mind are the main weapons of choice in most martial arts, but some employ swords and sticks. In addition to basic defense and offense, most types of martial arts embody self discipline and spirituality.

East Asian martial arts are all heavily influenced by each other, often when a practitioner of a certain style traveled to another region to share teachings. Borders and sovereignty influenced the spread of dominant martial art styles and the Japanese occupation of Korea, China and the Ryukyu Islands (Okinawa) had a profound affect on the spread of popular styles. Almost without exception, all martial arts have strikes, grabs, holds and traditional forms of movement (poomse in Korea, Kata in Japan, and Taolu in China) and employ some system of spiritual philosophy.

This article is not meant to be a comprehensive history of all martial arts, but rather a summary of the different styles designed to help you decide which sport works best for you.

Korean Martial Arts – in Korean, “do” as in “taekwondo and hapkido” means the “art or method of”.

Taekwondo – Translates into the method of striking with hand and foot. Taekwondo uses both the upper and lower extremities but its main focus is on kicking. Taekwondo is a Summer Olympic Sport and is governed by the World Taekwondo Federation, headquartered in Seoul, South Korea, although formally, there are two branches of taekwondo world wide; the WTF and the International Taekwon-Do Federation. A student of taekwondo can expect to be trained in kicking, punching, open hand techniques, blocking, self defense, sparring and forms (poomse). The Korean military trains their soldiers in taekwondo and it is the national sport of South Korea.

Hapkido – Roughly translated, means the “way of coordinating energy”. Hapkido focuses on self defense, and using the  opponent’s momentum against them in a circular technique. This sport uses pressure points, joint locks, striking, throwing and pinning techniques. Like taekwondo, Hapkido places a strong emphasis on kicking; focused mainly on unbalancing your opponent with strikes below the waist. Hapkido practitioners may also use swords, staffs, ropes and nunchaku.

China

Kung Fu – In Chinese, Kung Fu literally translates as “human achievement” and doesn’t have to be specific to martial arts. People in the west – for want of a better term – understand Kung Fu to be the Chinese style of martial arts popularized by Bruce Lee who taught his own form of martial arts called Jeet Kune Do. Like most martial arts, Kung Fu employs kicks, punches, grapples and weaponry with a strong focus on self defense. There are literally hundreds of different styles taught throughout China and beyond, the most famous being the Shaolin style. Shaolin monks combine mental and physical conditioning with spiritual practices to attain mind-body balance.

Japan

Sumo – a grappling martial art where two wrestlers in a circular ring win a bout by either forcing their opponent out of the ring, or to touch the ground with anything other than the soles of their feet. Although considered by some to be a modern Japanese martial art, Sumo dates back to the Edo period in Japan; roughly 1603 to the mid 1800′s. Sumo is linked also to the Shinto practice of ritual dance whereby a warrior wrestled with divine spirits.

Karate – at the risk of sounding repetitive, Karate is the art of using open and closed hand strikes, kicking, knee and elbow strike, pressure points and grappling. The Chinese and Japanese martial arts developed simultaneously and heavily influenced each other. Karate originated in the Ryukyu Islands; now known as Okinawa, Japan. Historically, the Ryukyu Islands had sovereignty separate from China and Japan; maintaining prosperous trade relationships with both countries. Fighting techniques and spiritual practices associated with Chinese martial arts heavily influenced the development of Karate and its spread to the main islands of Japan in the early 19th century.

Aikido – a grappling, defensive martial art designed to use the momentum of the opponent’s attack to throw them off balance; thus neutralizing the attack without causing great damage to the attacker. Aikido is based on the philosophy of universal peace and reconciliation and heavily influenced by the Omoto-Kyo religion where its practice seeks to show compassion and understanding to the attacker by inflicting minimal or no damage thwarting the attack. The modern practice of Aikido originated in the early 20th century and its subsequent spread to the rest of the world in the early 1950′s when Minoru Mochizuki traveled to France and taught Aikido to Judo students.

Judo and Jiu-Jitsu – both are grappling martial arts designed to subdue an attacker using a joint lock, hold or choking maneuver. Striking and weapon usage is not permitted in judo competition, but are used in katas. Judo’s main focus is in throws and ground fighting, and like many of its sister martial arts, focuses on using the momentum of the attacker to thwart the attack. Both Judo and Jujitsu are prefaced by “ju” which means “the soft method”, or indirect application of force. Judo’s signature moves are the floating hip and the shoulder wheel, developed by Kano Jigoro. It is important to understand, however, that Judo was born out of Jiu-Jitsu and despite their similarities, are separate martial arts. In the simplest terms, Judo is Jiu-Jitsu without the strikes.

Kendo and Chanbara – sword fighting martial arts that use a shinai (Kendo) or foam boffers (Chanbara) – shinai are woven bamboo practice sword to represent a katana – a single bladed, Samurai sword. These sports of Japanese fencing train the mind and body in one on one combat.

Brazil

Capoeira – combines dance, acrobatics and martial arts for use in self defense. Capoeiria began in Africa in the Congo and Angora but came to South America with African slaves who were brought to Brazil who used it as a means of self expression and defense in a “Dance of War”. Since arriving in Brazil over 400 years ago, Capoeira has become richly woven in the cultural fabric of Brazil. Capoeira martial artists traditionally form a ring of people who take turns singing, playing drums, and sparring. The sparring incorporates leg sweeps, kicks, strikes and throws. Sadly, and ironically, this martial art was banned in Brazil until the 1930′s and didn’t become popular until the 1970′s.  Up until this point, it was mainly practiced by the poor population in Brazil.

Brazilian Jiu-Jitsu – combines Japanese Judo and Jiu-Jitsu. Japanese Jiu-Jitsu’s rules have changed over the last decades; with less focus on groundwork.  Since these changes took place after Mitsuyo Maeda brought Jiu-Jitsu from Japan to Brazil, BJJ followed along more traditional lines of Jiu-Jitsu sparring – lots of groundwork and take downs. Carlos Gracie was Maeda’s first Brazilian student and his brother Helio is known as the father of Brazilian Jiu-Jitsu. BJJ permits more types of take downs and joint locks than Japanese Jiu-Jitsu – of particular note is the Flying Arm Bar popularized by MMA fighters. BJJ is largely responsible for popularizing ground fighting and submission holds and is the martial art of choice for fighters wanting to compete in Mixed Martial Arts competitions.

Other Martial Arts

Gatka – an Indian martial art of the Sikh people that uses swords, shields and other weapons to train the body and mind in discipline and self defense. It was originally taught the Sikhs by the Hindu people in the 1500′s, but has been preserved, despite the growing cultural invasions, as a martial art.

Bando Thaing – a Burmese martial art employing striking, kicking, grappling and fighting with different weapons.

What Does the Executive Branch Do?

This article refers to the United States government only.

Seal of the United States Department of Education

The U.S. government is divided into 3 interrelated branches; each with some degree of power over the other 2 branches in a system of checks and balances designed to prevent abuse of power: the Executive branch, the Judicial Branch and the Legislative Branch.

The Executive branch consists of the President, the Vice President; the Secretary of State, the various Federal Executive Departments; also referred to as the Cabinet; NASA, the Postmaster General, the EPA, the CIA and a few others. The cabinet officials are appointed by the president with the guidance and consent of the senate; one of the two bodies of Congress; another branch of the U.S. government. Congressional consent of Presidential appointments is an example of the checks and balances in place purported to prevent abuse of power from any one branch. Aside from the president and vice president, the Executive is the non-elected division of government, appointed by the president and serving at the president’s pleasure. There are 15 State Departments, each headed by an official referred to as a Secretary: State, Treasury, Defense, Justice, Interior, Agriculture, Commerce, Labor, Health and Human Services, Housing and Urban Development, Transportation, Energy, Education, Veteran’s Affairs and Homeland Security.

What Does the Attorney General Do?

Insignia for the D.O.J.

In the United States, the Attorney General is the head of the United States Department of Justice and the chief lawyer for the country. They are responsible for all law enforcement and legal matters. The A.G. is a member of the president’s cabinet, appointed by the president and serves at the president’s pleasure. They, along with the Postmaster General are the only cabinet members not to have the title of Secretary.

The A.G. is 7th in line for the presidency should something happen to the Vice President, Speaker of the House, President of the Senate, Secretary of State, Secretary of Treasury, or the Secretary of Defense.

What Does the Stomach Do?

Your entire digestive system.

Your stomach is located at the end of your esophagus and is the terminus for swallowed food and drink. The stomach receives chewed food and continues to mechanically and chemically break it down into smaller pieces, creating more surface area for your small intestine to absorb nutrients.

Your stomach is an acidic environment with a low pH of between 1 and 3. Parietal cells in the wall of the stomach secrete hydrochloric acid (HCl). If your esophageal sphincter; basically the lid to your stomach; isn’t closed properly, HCl will creep into your esophagus resulting in heartburn. HCl has a few different jobs. One, is to kill bacteria or other potentially dangerous pathogens you may have unknowingly ingested with your food. Another is to convert pepsinogen into pepsin. Pepsinogen is released from chief cells in your stomach wall. HCl, chemically changes pepsinogen into pepsin and is essential because pepsin doesn’t function in an environment with a pH greater than 5. Pepsin begins protein digestion by breaking it down into peptide chains. Peptide chains are made up of amino acids. Your small intestine absorbs amino acids into your circulatory system for distribution to the rest of your body. It is important to note there is a layer of mucus protecting your stomach from being chemically broken down by pepsin and HCl.

Parietal cells of stomach wall

Parietal cells in your stomach wall also secrete intrinsic factor; a substance whose only job – as far as scientists know – is to facilitate the absorption of  vitamin B-12.  Intrinsic factor cannot do its job in the acidic environment of your stomach; it works best in a pH of 7 – close to water – but is used later in your ileum to absorb vitamin B-12 into your circulatory system after bile from your gallbladder has neutralized the acidic chyme (what your partially digested food is called when it enters your small intestine). B-12 is vital for your red blood cells to carry oxygen. People who lack intrinsic factor, cannot absorb vitamin B-12 and suffer from pernicious anemia.

Chymosin, or rennin, is secreted by the chief cells in your stomach wall and is responsible for the breakdown of a specific peptide bond: phenylalanine and methionine, through a complicated chemical process that I won’t detail here. Interestingly, rennin is the active ingredient in rennet which is used the cheese production; compelling some vegetarians into eating cheese without rennet.

Gastric lipase (“lip” means fat and “ase” means breakdown) is secreted by the chief cells to begin fat digestion in your stomach by hydrolyzing (“hydro” means water and “lyzing” means breaking apart; so the breaking apart of a molecule using water) fat molecules into fatty acid chains. Further fat digestion happens in the small intestine with the addition of pancreatic lipase.

G-cells in the wall of your stomach secrete gastrin, a hormone responsible for stimulating the release of HCl from the parietal cells. Gastrin is a chemical messenger that travels in your bloodstream and is released when your stomach is distended from having recently eaten, or when directed to be released by your brain in response to the sight or smell of food. Gastrin stimulates the release of HCl and pepsinogen. It enhances the strength of your stomach contractions to aid in mechanical digestion and causes the pyloric sphincter to relax or contract, controlling movement of chyme that moves into duodenum, the first segment of the small intestine. Your duodenum can only process a certain amount of chyme at a time, so your pyloric sphincter opens and closes to allow small packets of chyme to enter at regular intervals.

In summary, your stomach breaks your food into smaller pieces and mixes it with all of the above secretions in mechanical digestion. Parietal cells secrete hydrochloric acid and intrinsic factor. Chief cells secrete pepsinogen, chymosin and gastric lipase. Mucus cells secrete mucus to protect the stomach wall from the acidic chyme. Gastrin is the hormone responsible for mobilizing the whole process.

What Does the Colon Do?

The colon is the biggest part of the large intestine. Your entire intestinal tract between your stomach and your anus includes your small intestine that is divided into the duodenum, the jejunum and the ileum. Your large intestine is made up of your cecum, ( in anatomical order) the ascending, transverse, descending and sigmoid colon, rectum and anus.

The cecum is the small sac that connects to the ileum of the small intestine to the ascending colon. Chyme is the mostly digested food matter that enters the cecum from the small intestine. 90% of digestion has already taken place. The colon has no digestive enzymes, but positive intestinal bacteria called gut flora and mucus are added to the chyme to form feces. At this point, your body will reclaim water and vitamins; essentially concentrating the feces before it exits the body. Note; when you have watery poop, your colon is not reabsorbing water and vitamins from the feces; the last step in digestion is being skipped. This is one of the reasons why it is so important to stay hydrated when you have diarrhea.

One type of gut flora - Candida albicans

Now, a word about dietary fiber. We are constantly reminded to eat lots of fiber for colon health. But why? The bacteria in your large intestine consume the largely undigested fiber for their own sustenance, and give off acetate, propionate and butyrate as waste products which the cell lining of the large intestine uses as nutrients. It really is amazing how efficient our bodies are; the 3 R’s to the extreme.

What can go wrong?

Colitis (“col” is colon and “itis” means inflammation), not matter what the cause is a swelling of the large intestinal wall. It can caused by autoimmune processes, idiopathic (of unknown cause), vascular (an interruption of blood flow to a portion of the intestine), infectious (as is the case with clostridium difficile and e coli), or caused by parasites.

Hereditary or other causes of colorectal cancer affect approximately 7% of U.S. citizens.

Crohn’s disease is an autoimmune disorder where the body attacks the colon wall, causing colitis.

What Does the Bladder Do?

Major elements of the urinary system

The urinary bladder, as it is referred to anatomically to distinguish it from meaning “pouch or flexible enclosure”, sits atop your pelvic floor: protective layers of muscles and connective tissues designed to hold you internal organs in place. The bladder is the final internal destination for urine that has been collected and concentrated by the kidney and transported via the ureters – one for each kidney.

The urinary bladder; like the design of many other internal surfaces of your body, like the small intestine and the stomach is lined with folds of tissue. In the stomach and bladder, these folds are called rugae and they stretch and flatten in response to increased pressure – if you have just eaten a big meal or haven’t urinated in a long time. Our wonderful bodies follow this design because internal bladder expansion takes the pressure off the surrounding pelvic and abdominal organs. In contrast, if the bladder filled outwards like a balloon, our pelvic and abdominal muscles would be continually squashed.

We start feeling the urge to pee when our bladder is about 25% full. For most people; this pretty easy to ignore. Nerves on and near our bladder, when stretched, trigger the parasympathetic nervous system (the rest and digest part of our nervous system as opposed to the sympathetic fight or flight part of our nervous system) to signal us to go pee. As the bladder stretches, the PNS becomes more insistent that we go pee. If the bladder reaches 100% capacity you will expel urine involuntarily. The flow of urine is controlled by two muscles; an internal involuntary muscle called the detrusor muscle and an external voluntary Kegel muscle.

OK, a brief aside to explain involuntary and voluntary muscle: involuntary muscles are controlled directly by our nervous system without conscious input from us. They are made up of smooth muscle fibres. Skeletal muscle, under our voluntary control is also regulated by our nervous system, but we are the ones sending the signals to the brain to move or not move. Skeletal muscle is striated. Microscopically, they look very different from each other. Smooth muscles are working away in your body all the time; like for example, in your small intestine as the smooth muscles push food along the digestive tract towards the large intestine (or colon) and out the anus.

Kegel muscle a.k.a. the Pubococcygeus muscle

It is our voluntary muscle we contract to “hold pee in” You can strengthen this muscle by doing Kegel exercises – for women, flexing the little ring of muscles, inside your vaginal opening. Doing about 25 flexes of this muscle every day well help to prevent urinary incontinence problems when you are older. Men also have a Kegel muscle that allows their penis to stay erect, and controls their ejaculation and of course, help with incontinence. Men can isolate and strengthen this muscle by stopping and starting the flow when urinating. This is the same for women.

What can go wrong? Well it all boils down to incontinence, but for many different reasons. If you have damaged nerves, you may not be able to receive the PNS’s signals urging you to urinate as is the case with some Parkinson’s and Multiple Sclerosis patients. Your detrusor muscle (involuntary) is controlled by the PNS. If your PNS is damaged, this muscle may not function properly, and the only protection you have is your external muscle; which is likely not strong enough to hold back small outputs of urine. Prostate cancer can damage pelvic nerves resulting in incontinence.

Sometimes (mostly in women), if you laugh, sneeze or cough, the pressure it creates overcomes both sets of muscles resulting in little spurts of urine coming out. This is called Stress Incontinence and happens mostly in older women – over the age of 60, but can happen younger; say if you have a genetic predisposition to urinary incontinence.

Overactive bladder is diagnosed when you have to pee 8 or more times a day, and are up 1 or 2 times a night. Based on this definition approximately 1 in 6 people in the U.S. have this problem. OAB can be treated with antimuscarinic drugs or through a really cool sounding procedure whereby physicians insert an electrode near the tibial nerve in your leg. An electrical impulse travels to your sacral plexus via your tibial nerve. Recall, that your tibia is a bone in your lower leg. Your sacral plexus is a bundle of nerve fibers responsible for controlling parts of your pelvis and lower extremities. The treatment takes place once a week for 12 weeks. Some patients need more or ongoing treatment. I myself have an overactive bladder, but it doesn’t badly interfere with my life – excepting 11 hour long bus rides in Central Turkey with only one bathroom stop; I have just lived with it without treatment. Please understand, I am not a medical professional and I am not advocating any procedure or treatment, but just seek to educate people about our bodies and how they work. Peace out.